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B263 low concentrations of ampicillin used in combination with rifampin may give an additive or synergistic effect; however high ampicillin concentrations may result in antagonism.
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Ampicillin is a pnicillin bta-lactam antibiotic usd in th tatmnt bactial inctions causd by suscptibl, usually gam-positiv, oganisms. Th nam “pnicillin” can ith tsval vaiants pnicillin availabl, tth goup antibiotics divd om th pnicillins. Ampicillin has in vitactivity against gam-positiv and gam-ngativ aobic and anaobic bactia. Th bacticidal activity Ampicillin sults om th inhibition cll wall synthsis and is mdiatd though Ampicillin binding tpnicillin binding potins (PBPs). Ampicillin is stabl against hydolysis by a vaity bta-lactamass, including pnicillinass, and cphalospoinass and xtndd spctum bta-lactamass.
At tatmnt with ampicillin, a als-positiv action glucos in th uin may occu with copp sulat tsts (Bndict’s solution, hling’s solution, Clinitst tablts) but not with nzym basd tsts such as Clinistix and Glucos nzymatic Tst Stip USP.
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later, these were followed by ampicillin, cloxacillin and others, as the group focused on pharmaceutical development.